Muscle production can be achieved without exercising with a new gene therapy

Could we have thought of a world where it would be real to have a muscular appearance without exercising, and to avoid obesity without dieting?

Muscle production can be achieved without exercising with a new gene therapy

Could we have thought of a world where it would be real to have a muscular appearance without exercising, and to avoid obesity without dieting? A new gene therapy that scientists have discovered makes this possible.

A new study conducted by scientists from the University of Washington School of Medicine in the USA revealed that obesity can be prevented and muscle can be done without the need for exercise with a new gene therapy performed on mice fed a high-fat diet.

Follistatin, a protein found in almost all animal tissues, was first discovered and described in the late 1980s. Follistatin, originally explored for its role on reproductive hormone, was later discovered to affect many cellular processes, including the production of muscle cells.

New gene therapy promises to prevent muscle and bone problems from obesity

Could we have thought of a world where it would be real to have a muscular appearance without exercising, and to avoid obesity without dieting?

Previous studies on animals have shown that gene treatments designed to increase follistatin expression (the process of transformation of genes into functional protein structures) can counteract some degenerative muscle diseases. New research has also investigated whether this type of therapy can help treat osteoarthritis (calcification) by increasing muscle mass and reducing metabolic damage due to obesity.

The study’s senior researcher, Farshid Guilak, noted that although the mice were fed a high-fat diet and did not exercise above normal, muscle mass formation occurred without weight, and the results were impressive. In addition, it was revealed that the gene therapy applied alleviated bone and joint injuries due to obesity.

Could we have thought of a world where it would be real to have a muscular appearance without exercising, and to avoid obesity without dieting?

New research shows that follistatin gene therapy creates multifactorial effects such as not only affecting muscle mass, but also large metabolic activities that can somehow meet calorie intake in high-fat diets.

Guilak says, however, that we have many years ahead of us for clinical testing that can be performed on humans. However, this promising finding points to gene treatments that can treat obesity or build muscle in people who can’t exercise without major dietary changes. The new research has been published in the journal Science Advances.

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